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Sickle Cell Anemia

/Sickle Cell Anemia
Sickle Cell Anemia 2018-02-12T05:49:09+00:00

Sickle cell disease is a disorder of the blood caused by inherited abnormal hemoglobin (the oxygen-carrying protein within the red blood cells). The abnormal hemoglobin causes distorted (sickled) red blood cells. The sickled red blood cells are fragile and prone to rupture.

Inheritance Pattern

A person with SCD can pass the disease on to his or her children. Sickle cell trait (SCT) is not a disease, but means that a person has inherited the sickle cell gene from one of his or her parents. with SCD with every pregnancy. When both parents have SCT, they have 50% chance of having affected child.

Diagnosis

Molecular analysis of of HBS gene will be performed to diagnose a patient through ARMS-PCR method or direct sequence analysis of the HBS gene.